Model-Based Clustering of Longitudinal Data: Application to Modeling Disease Course and Gene Expression Trajectories
نویسندگان
چکیده
6 We consider the problem of clustering time dependent data. The model is 7 a mixture of regressions, with variance-covariance matrices that are allowed 8 to vary within the extended linear mixed model family. We discuss appli9 cations to biomedical data and analyze two longitudinal data sets: one on 10 patients with delirium, and the other on mosquito gene expression following 11 infection. 12
منابع مشابه
Modification of the Fast Global K-means Using a Fuzzy Relation with Application in Microarray Data Analysis
Recognizing genes with distinctive expression levels can help in prevention, diagnosis and treatment of the diseases at the genomic level. In this paper, fast Global k-means (fast GKM) is developed for clustering the gene expression datasets. Fast GKM is a significant improvement of the k-means clustering method. It is an incremental clustering method which starts with one cluster. Iteratively ...
متن کاملApplication of Gene Expression Programming and Support Vector Regression models to Modeling and Prediction Monthly precipitation
Estimating and predicting precipitation and achieving its runoff play an important role to correct management and exploitation of basins, management of dams and reservoirs, minimizing the flood damages and droughts, and water resource management, so they are considered by hydrologists. The appropriate performance of intelligent models leads researchers to use them for predicting hydrological ph...
متن کاملAssessment of the Performance of Clustering Algorithms in the Extraction of Similar Trajectories
In recent years, the tremendous and increasing growth of spatial trajectory data and the necessity of processing and extraction of useful information and meaningful patterns have led to the fact that many researchers have been attracted to the field of spatio-temporal trajectory clustering. The process and analysis of these trajectories have resulted in the extraction of useful information whic...
متن کاملDeveloping a Course Recommender by Combining Clustering and Fuzzy Association Rules
Each semester, students go through the process of selecting appropriate courses. It is difficult to find information about each course and ultimately make decisions. The objective of this paper is to design a course recommender model which takes student characteristics into account to recommend appropriate courses. The model uses clustering to identify students with similar interests and skills...
متن کاملCluster-based network model for time-course gene expression data.
We propose a model-based approach to unify clustering and network modeling using time-course gene expression data. Specifically, our approach uses a mixture model to cluster genes. Genes within the same cluster share a similar expression profile. The network is built over cluster-specific expression profiles using state-space models. We discuss the application of our model to simulated data as ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Communications in Statistics - Simulation and Computation
دوره 41 شماره
صفحات -
تاریخ انتشار 2012